Regenerative Medicine Amniotic Fluid Joint Injections

AmnioFlo is processed at Bone Bank Allografts (est. 1993) in Texas. The data on amniotic tissue and fluid goes back over 100 years. Most recent advancements in this space allowed for the processing of the tissue and fluid to be in a stable format that can sit in ambient conditions for years while still retaining all the beneficial factors that we know about this acellular allograft (cytokines, growth factors, hyaluronic acid) that result in moderation of inflammation, accelerated healing, antibacterial properties, reduced fibrosis/scarring and decreased pain. All this plus a very long track record of safety.

References for Bone Bank Allografts Products

  • Nyman E, Huss F, Nyman ‘T, Junker J, Kratz G. (2013 Apr) Hyaluronic acid, an important factor in the wound healing properties of amniotic fluid: in vitro studies of re-epithelialisation in human skin wounds. J Plast Surg Hand Surg. 47(2):89-92
  • Adzick NS, Lorenz HP. (1994 Jul) Cells, matrix, growth factors, and the surgeon. The biology of scarless fetal wound repair. Annals of Surgery;220(1):10-18.
  • Gao X, Devoe LD, Given KS. (1994 Aug) Effects of amniotic fluid on proteases: a possible role of amniotic fluid in fetal wound healing. Annals of Plastic Surgery. 33(2):128-134; discussion 134-135.
  • Bolat E, Kocamaz E, Kulahcilar Z, Yilmaz A, Topcu A, Ozdemir M, Coskun ME. (2013 Dec) Investigation of efficacy of mitomycin-C, sodium hyaluronate and human amniotic fluid in preventing epidural fibrosis and adhesion using a rat laminectomy model. Asian Spine J. 7(4):253-9.
  • Cobanglu U, Kutlu N, Karacal N, Kosucu P. (2005 Dec) Effect of human amniotic fluid on bone healing, J Surg Res.129(2):283-7.
  • Ozgenel GY, Filiz G, Ozcan M. (2004 Jul) Effects of human amniotic fluid on cartilage regeneration from free perichondrial grafts in rabbits. Br J Plast Surg. 57(5):423-8.

References

  1. Nyman E, Huss F, Nyman T, Junker J, Kratz G. (2013 Apr) Hyaluronic acid, an important factor in the wound healing properties of amniotic fluid: in vitro studies of re-epithelialisation in human skin wounds. J Plast Surg Hand Surg. 47(2):89-92
  2. Adzick NS, Lorenz HP. (1994 Jul) Cells, matrix, growth factors, and the surgeon. The biology of scarless fetal wound repair. Annals of Surgery.;220(1):10-18.
  3. Gao X, Devoe LD, Given KS. 1994 Aug) Effects of amniotic fluid on proteases: a possible role of amniotic fluid in fetal wound healing. Annals of Plastic Surgery. 332)128-134; discussion 134-135.
  4. Bolat E, Kocamaz E, Kulahcilar Z, Yilmaz A, Topcu A, Ozdemir M, Coskun ME. (2013 Dec) Investigation of efficacy of mitomycin-C, sodium hyaluronate and human amniotic fluid in preventing epidural fibrosis and adhesion using a rat laminectomy model. Asian Spine J. 7(4):253-9.
  5. Ozgenel GY, Filiz G, Ozcan M. (2004 Jul) Effects of human amniotic fluid on cartilage regeneration from free perichondrial grafts in rabbits. Br J Plast Surg. 57(5):423-8.
  6. Rosner M, Hipany K, Shanmugasundaram B, Lubec G, Hengstschlager M (2012 Jun) Amniotic Fluid Stem Cells: Future Perspectives. Stem Cells Int. 2012: 741810.

Scientific Background and Reference Sources

  • Koob TJ, Rennert R, Zabek N, et al. Biological properties of dehydrated human amnion/chorion composite graftะ implications for chronic wound healing. Int Wound J. Oct 2013;10(5):493-500. PMID 23902526
  • Zelen CM, Poka A, Andrews J. Prospective, randomized, blinded, comparative study of injectable micronized dehydrated amniotic/chorionic membrane allograft for plantar fasciitis—a feasibility study. Foot Ankle Int. Oct 2013;34(10):1332-1339. PMID 23945520
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